Beautiful LYSISTRATA (Teyonah Parris) is in love with aspiring Rapper DEMTRIUS "CHI-RAQ" DUPREE (Nick Cannon), but she is disturbed by the bloody warbetween his Spartan gang and the
rival Trojans, led by CYCLOPS (Wesley Snipes). After Trojans set fire to her apartment while she's in bed with Chi-Raq(pronounced Shy-RACK), Lysistrata moves in with her neighbor MISS HELEN (Angela Bassett), a book-loving Peace activist who lost her daughter years before to a stray bullet.
When Patti, an 11-year-old neighborhood girl, is accidentally killed in a drive-by shooting, her grieving mother IRENE (Jennifer Hudson) pleads with anyone who witnessed the crime to come forward. But even after a reward is offered by a local Church congregation led by fiery anti-gun-violence activist FR. MIKECORRIDAN (John Cusack), no one is willing to identify the killer.